Background: Type-specific high-risk HPV (hrHPV) infection is related to cervical carcinogenesis. The prevalence of\nhrHPV infection varies geographically, which might reflect the epidemiological characteristics of cervical cancer\namong different populations. To establish a foundation for HPV-based screening and vaccination programs in China,\nwe investigated the most recent HPV prevalence and genotypic distributions in different female age groups and\ngeographical regions in China.\nMethods: In 2012, a total of 120,772 liquid-based cytological samples from women enrolled for population- or\nemployee-based cervical screening in 37 Chinese cities were obtained by the Laboratory of Molecular Infectious\nDiseases of Guangzhou KingMed. A total of 111,131 samples were tested by Hybrid Capture II and the other\n9,641 were genotyped using the Tellgenplexââ??¢ HPV DNA Assay.\nResults: The total positive rate for hrHPV was 21.07 %, which ranged from 18.42 % (Nanchang) to 31.94 % (Haikou)\nand varied by region. The regions of Nanchang, Changsha, Hangzhou, Chengdu, Fuzhou, Guangdong, and Guiyang\ncould be considered the low prevalence regions. Age-specific prevalence showed a ââ?¬Å?two-peakââ?¬Â pattern, with the\nyoungest age group (15ââ?¬â??19 years) presenting the highest hrHPV infection rate (30.55 %), followed by a second\npeak for the 50ââ?¬â??60-year-old group. Overall, the most prevalent genotypes were HPV16 (4.82 %) and HPV52 (4.52 %),\nfollowed by HPV58 (2.74 %). Two genotypes HPV6 (4.01 %) and HPV11 (2.29 %) were predominant in the low-risk HPV\n(lrHPV) type, while the mixed genotypes HPV16 + 52 and HPV52 + 58 were most common in women with multiple\ninfections.\nConclusions: This study shows that HPV infection in China has increased to the level of an ââ?¬Å?HPV-heavy-burdenââ?¬Â zone in\ncertain regions, with prevalence varying significantly among different ages and regions. Data from this study represent\nthe most current survey of the nationwide prevalence of HPV infection in China, and can serve as valuable reference to\nguide nationwide cervical cancer screening and HPV vaccination progra
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